Under Eye Rejuvenation with Platelet- Rich Plasma (PRP)

Dr. Elizabeth Miller N.D.

This consult is in place for your safety, and for determining if you are a suitable candidate for the treatment. Certain underlying health conditions PRP may be contraindicated such as uncontrolled diabetes, infection, recent history of cancer and liver disease.  During this consult we discuss if a partial or full treatment would be best suited to you.  Beyond these items, I review general health symptoms and recent laboratory testing.  When indicated, laboratory testing may be recommended prior to starting treatment to investigate underlying causes for the hair loss that may impede your success with PRP.

Dark circles come with certain genetics, lifestyle factors, and of course with age. Their presence can be stressful to the psyche, as they can give the appearance of fatigue and feeling unrefreshed, even with the best night’s sleep.

As we age, there are multiple factors that contribute to periorbital changes. Such factors include: thinning tissue, loss of collagen and hyaluronic acid, increased pigmentation, wrinkles/fine lines and changes in ligament and bone structure.

Fortunately, if you find eye creams just aren’t enough, there are many minimally invasive treatments that can help with this common aging concern. Well known treatments include energy systems such as IPL and RF lasers, chemical peels, dermabrasion, neuromodulators, topical prescriptions and soft tissue fillers (1).

A recent systemic review in the Journal of Cosmetic Dermatology brings PRP to the table as a tool in minimally invasive periorbital rejuvenation (1). PRP works by increasing the dermal fibroblast proliferation, expression of matrix metalloproteinase, collagen synthesis, and secretion of endogenous hyaluronic acid (1). In other words, it stimulates your body’s repair of photoaging, pigmentation, wrinkling and volume loss (1, 2, 3,4,5). Research typically indicates a series of 3 facial PRP treatments are required to receive satisfactory results (6), however results have also been obtained in the peri-orbital region after a single treatment (2).

PRP is natural. A small sample of blood is drawn, and then spun to separate the platelets into a higher density and remove red and white blood cells.  A numbing cream is applied to the face prior to the treatment to minimize any discomfort.  The PRP is injected to desired locations on the face.  After the procedure, you may experience minor swelling lasting up to 24 hours, and on occasion mild bruising.  If microneedling is also completed, you can expect redness, similar to that of sunburn for the remainder of the day, up to 24hrs.

Elizabeth Miller, ND

  1. Kassir M, Kroumpouzos G, Puja P, et al. Update in minimally invasive periorbital rejuvenation with a focus on platelet-rich plasma. A narrative review. J Cosmet Dermatol. 2020;19:1057-1062.
  2. Mehryan  P,  Zartab  H,  Rajabi  A,  et  al.  Assessment  of  efficacy  of platelet rich plasma (PRP) on infraorbital dark circles and crow’s feet wrinkles. J Cosmet Dermatol. 2014;13(1):72-78.
  3. Elnehrawy  NY, Ibrahim  ZA,  Eltoukhy  AM,  Nagy  HM.  Assessment of the efficacy and safety of single platelet-rich plasma injection on different types and grades of facial wrinkles. J Cosmet Dermatol. 2017;16:103-111. 52.  Cameli  N,  Maria
  4. Cameli  N,  Mariano  M,  Cordone  I,  Abril  E,  Masi  S,  Foddai  ML. Autologous pure platelet-rich plasma dermal injections for facial skin rejuvenation. Dermatol Surg. 2017;43(6):826-835.
  5. Anitua E, Sánchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, Andía I. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009 Apr;42(2):162-70. doi: 10.1111/j.1365-2184.2009.00583.x. Epub 2009 Feb 24. PMID: 19250293; PMCID: PMC6496288.
  6. Al-Shami  SH.  Treatment of periorbital  hyperpigmentation using platelet-rich plasma injections. Am J Dermatol Venereol. 2014;3(5):87-94.